Effects of radiofrequency radiation on colorectal cancer cell proliferation and inflammation
نویسندگان
چکیده
Abstract Objectives The aim of this study is to investigate the effects radiofrequency radiation (RFR) on apoptosis, proliferation, stress response, and inflammation markers in colorectal cancer cells. Methods We tested intermittent exposure RFR at different frequencies two cell lines; HCT-116 DLD-1. Protein levels were subsequently analyzed by ELISA. Results led a decrease P53, p-P53, p-P38, p-IkB cells, while leading an increase BAD, p-BAD, p-STAT3,NF-κB levels. Two thousand one hundred Megahertz altered NF-ΚB expression NF-κB, p-NF-κB, p-SAPK/JNK, p-STAT3, increased after 900 2,100 MHz DLD-1 Unlike 1,800 was reported have no effect DLD1 Conclusions apoptosis inflammatory response HCT116 lowering active P38 P53 levels, which are indicators poor prognosis several cancers. Genetic differences, such as mutation (DLD-1), critical RFR, explains reason why scientific studies yield contradictory results.
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ژورنال
عنوان ژورنال: Türk biyokimya dergisi
سال: 2021
ISSN: ['1303-829X']
DOI: https://doi.org/10.1515/tjb-2020-0148